Sequence-specificity is the key to effective genetic targeting. With specificity, targeted genes
can be manipulated in multiple ways; without it, gene therapy agents become loose canons …

Rationale: Sleep disturbance during intensive care unit (ICU) admission is common and
severe. Sleep disturbance has been observed in survivors of critical illness even after …

Background Daily rhythms are observed in humans and almost all other organisms. Most of
these observed rhythms reflect both underlying endogenous circadian rhythms and evoked …

Background Multiple factors are believed to contribute to disruption of patients' sleep and
negatively affect clinical outcomes in the intensive care unit. Achieving restorative sleep for …

The severe acute respiratory syndrome coronavirus 2 pandemic poses extraordinary
challenges. The tremendous number of coronavirus disease 2019 (COVID-19) cases in the …

Objectives To evaluate the feasibility of using unattended, portable polysomnography (PSG)
to measure sleep among patients in the medical intensive care unit (MICU). Background …

Background: Sleep and circadian disruption (SCD) is common and severe in the ICU. On the
basis of rigorous evidence in non-ICU populations and emerging evidence in ICU …

Rationale: Poor sleep affects a majority of critically ill patients and is believed to be
associated with adverse intensive care unit (ICU) outcomes such as delirium. While recent …

Critical illness leading to ICU admission creates and propagates a syndrome of sleep loss,
poor sleep quality, and circadian misalignment. This syndromic entity is summarized with the …

Background In medical intensive care unit (MICU) patients, the predictors of post-discharge
sleep disturbance and functional disability are poorly understood. ICU delirium is a risk …