Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used to alleviate symptoms
during community-acquired pneumonia (CAP), while neither clinical data nor guidelines …

Background Community-acquired pneumonia (CAP) guidelines have improved the
treatment and outcomes of patients with CAP, primarily by standardization of initial empirical …

Background Whether noninvasive ventilation should be administered in patients with acute
hypoxemic respiratory failure is debated. Therapy with high-flow oxygen through a nasal …

Importance Severe pneumonia with hyperinflammation and elevated interleukin-6 is a
common presentation of coronavirus disease 2019 (COVID-19). Objective To determine …

The influenza H1N1 epidemics in 2009 led a substantial number of people to develop
severe acute respiratory distress syndrome and refractory hypoxemia. In these patients …

Background Awake prone positioning has been reported to improve oxygenation for patients
with COVID-19 in retrospective and observational studies, but whether it improves patient …

ContextMany physicians believe that the pulmonary artery catheter (PAC) is useful for the
diagnosis and treatment of cardiopulmonary disturbances; however, observational studies …

Background Patients with COVID-19 who develop severe acute respiratory distress
syndrome (ARDS) can have symptoms that rapidly evolve to profound hypoxaemia and …

The clinical pulmonary infection score—original or modified—has been proposed for the
diagnosis and management of ventilator-associated pneumonia. In 79 episodes of …

Background Whether the route of early feeding affects outcomes of patients with severe
critical illnesses is controversial. We hypothesised that outcomes were better with early first …