Background Respiratory tract infections with Pseudomonas aeruginosa occur in most
people with cystic fibrosis (CF). Established chronic P aeruginosa infection is virtually …

Background Inhaled antibiotics are commonly used to treat persistent airway infection with
Pseudomonas aeruginosa that contributes to lung damage in people with cystic fibrosis …

There remain many treatment uncertainties in cystic fibrosis (CF). With limited resources,
research should focus on questions which are most important to the CF community. We …

Background Cystic fibrosis is a genetic disorder in which abnormal mucus in the lungs is
associated with susceptibility to persistent infection. Pulmonary exacerbations are when …

Abstract In a recent James Lind Alliance Priority Setting Partnership in cystic fibrosis (CF) the
top priority clinical research question was:“What are effective ways of simplifying the …

TCR signal strength is involved in many cell fate decisions in the T-cell lineage. Here, we
show that transcriptional events induced by Hedgehog (Hh) signaling reduced TCR signal …

Abstract We show that Indian Hedgehog (Ihh) regulates T-cell development and
homeostasis in both fetal and adult thymus, controlling thymocyte number. Fetal Ihh−/− thymi …

Hedgehog signaling regulates differentiation, survival, and proliferation of the earliest
double-negative (DN) thymocytes, but its importance at later stages of T-cell development is …

Introduction “What effective ways of motivation, support and technologies help people with
cystic fibrosis improve and sustain adherence to treatment?” was identified as one of the …

The Hedgehog (Hh) signalling pathway influences multiple stages of murine T-cell
development. Hh signalling mediates transcriptional changes by the activity of the Gli family …