Blood pressure, stroke, and coronary heart disease: part 2, short-term reductions in blood pressure: overview of randomised drug trials in their epidemiological context
R Collins, R Peto, S MacMahon, J Godwin, N Qizilbash… - The Lancet, 1990 - Elsevier
There are 14 unconfounded randomised trials of antihypertensive drugs (chiefly diuretics or
beta-blockers): total 37 000 individuals, mean treatment duration 5 years, mean diastolic …
beta-blockers): total 37 000 individuals, mean treatment duration 5 years, mean diastolic …
Beta blockade during and after myocardial infarction: an overview of the randomized trials
S Yusuf, R Peto, J Lewis, R Collins, P Sleight - Progress in cardiovascular …, 1985 - Elsevier
An imbalance in oxygen supply and demand......................................................................... 337
Experimental evidence for possible mechanisms of benefit from beta blockade in acute MI …
Experimental evidence for possible mechanisms of benefit from beta blockade in acute MI …
[HTML][HTML] Interpretation of the evidence for the efficacy and safety of statin therapy
R Collins, C Reith, J Emberson, J Armitage, C Baigent… - The Lancet, 2016 - thelancet.com
This Review is intended to help clinicians, patients, and the public make informed decisions
about statin therapy for the prevention of heart attacks and strokes. It explains how the …
about statin therapy for the prevention of heart attacks and strokes. It explains how the …
[HTML][HTML] UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age
UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of
Complex Diseases of Middle and Old Age | PLOS Medicine Skip to main content …
Complex Diseases of Middle and Old Age | PLOS Medicine Skip to main content …
Blood pressure, stroke, and coronary heart disease: part 1, prolonged differences in blood pressure: prospective observational studies corrected for the regression …
S MacMahon, R Peto, R Collins, J Godwin, J Cutler… - The Lancet, 1990 - Elsevier
The associations of diastolic blood pressure (DBP) with stroke and with coronary heart
disease (CHD) were investigated in nine major prospective observational studies: total 420 …
disease (CHD) were investigated in nine major prospective observational studies: total 420 …
Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo …
Background The lowering of cholesterol concentrations in individuals at high risk of
cardiovascular disease improves outcome. No study, however, has assessed benefits of …
cardiovascular disease improves outcome. No study, however, has assessed benefits of …
Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as …
Background The apparent shortfall in prevention of coronary heart disease (CHD) noted in
early hypertension trials has been attributed to disadvantages of the diuretics and β blockers …
early hypertension trials has been attributed to disadvantages of the diuretics and β blockers …
[HTML][HTML] SARS-CoV-2 is associated with changes in brain structure in UK Biobank
There is strong evidence of brain-related abnormalities in COVID-19,,,,,,,,,,,–. However, it
remains unknown whether the impact of SARS-CoV-2 infection can be detected in milder …
remains unknown whether the impact of SARS-CoV-2 infection can be detected in milder …
Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials.
C Baigent, L Blackwell, R Collins, J Emberson… - …, 2009 - researchonline.lshtm.ac.uk
BACKGROUND: Low-dose aspirin is of definite and substantial net benefit for many people
who already have occlusive vascular disease. We have assessed the benefits and risks in …
who already have occlusive vascular disease. We have assessed the benefits and risks in …
[HTML][HTML] The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a …
C Baigent, MJ Landray, C Reith, J Emberson… - The Lancet, 2011 - thelancet.com
Background Lowering LDL cholesterol with statin regimens reduces the risk of myocardial
infarction, ischaemic stroke, and the need for coronary revascularisation in people without …
infarction, ischaemic stroke, and the need for coronary revascularisation in people without …