User profiles for "author:Ruth Tal-Singer"
Ruth Tal-SingerTalSi Translational Medicine Consulting, LLC Verified email at enarespiratory.com Cited by 28001 |
Blood fibrinogen as a biomarker of chronic obstructive pulmonary disease
Background Chronic obstructive pulmonary disease (COPD) is a multicomponent condition
that is characterised by airflow obstruction that is not fully reversible and is a major global …
that is characterised by airflow obstruction that is not fully reversible and is a major global …
Lessons from ECLIPSE: a review of COPD biomarkers
The Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points
(ECLIPSE) study was a large 3-year observational controlled multicentre international study …
(ECLIPSE) study was a large 3-year observational controlled multicentre international study …
Treatment trials in young patients with chronic obstructive pulmonary disease and pre–chronic obstructive pulmonary disease patients: time to move forward
Chronic obstructive pulmonary disease (COPD) is the end result of a series of dynamic and
cumulative gene–environment interactions over a lifetime. The evolving understanding of …
cumulative gene–environment interactions over a lifetime. The evolving understanding of …
[HTML][HTML] Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype
A Agustí, LD Edwards, SI Rennard, W MacNee… - PloS one, 2012 - journals.plos.org
Background Because chronic obstructive pulmonary disease (COPD) is a heterogeneous
condition, the identification of specific clinical phenotypes is key to developing more effective …
condition, the identification of specific clinical phenotypes is key to developing more effective …
[HTML][HTML] Characterisation of COPD heterogeneity in the ECLIPSE cohort
Background Chronic obstructive pulmonary disease (COPD) is a complex condition with
pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of …
pulmonary and extra-pulmonary manifestations. This study describes the heterogeneity of …
[HTML][HTML] Changes in forced expiratory volume in 1 second over time in COPD
J Vestbo, LD Edwards, PD Scanlon… - … England Journal of …, 2011 - Mass Medical Soc
Background A key feature of chronic obstructive pulmonary disease (COPD) is an
accelerated rate of decline in forced expiratory volume in 1 second (FEV1), but data on the …
accelerated rate of decline in forced expiratory volume in 1 second (FEV1), but data on the …
[HTML][HTML] Identification and initial characterization of four novel members of the interleukin-1 family
S Kumar, PC McDonnell, R Lehr, L Tierney… - Journal of Biological …, 2000 - ASBMB
Interleukin-1 (IL-1), fibroblast growth factors (FGFs), and their homologues are secreted
factors that share a common β-barrel structure and act on target cells by binding to cell …
factors that share a common β-barrel structure and act on target cells by binding to cell …
[HTML][HTML] Comorbidity, systemic inflammation and outcomes in the ECLIPSE cohort
J Miller, LD Edwards, A Agustí, P Bakke… - Respiratory …, 2013 - Elsevier
Comorbidities, are common in COPD, have been associated with poor outcomes and are
thought to relate to systemic inflammation. To investigate comorbidities in relation to …
thought to relate to systemic inflammation. To investigate comorbidities in relation to …
Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease
BR Celli, N Locantore, J Yates… - American journal of …, 2012 - atsjournals.org
Rationale: Accurate prediction of mortality helps select patients for interventions aimed at
improving outcome. Objectives: Because chronic obstructive pulmonary disease is …
improving outcome. Objectives: Because chronic obstructive pulmonary disease is …
Eosinophilic inflammation in COPD: prevalence and clinical characteristics
D Singh, U Kolsum, CE Brightling… - European …, 2014 - Eur Respiratory Soc
Eosinophilic inflammation is thought to be a characteristic feature of asthma rather than
COPD. However, studies have shown that a subset of COPD patients with eosinophilic …
COPD. However, studies have shown that a subset of COPD patients with eosinophilic …