The discovery of anti-cancer drugs has become dependent on cell lines, which are used to
screen potential compounds for activity as well as to explore cancer biology. Cell lines …

We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70
in multiple independent lineages, often occurring after acquisition of receptor binding motif …

This review summarises molecular pathological techniques applicable to thyroid FNA. The
molecular pathology of thyroid tumours is now fairly well understood. Molecular methods …

Background Tumor resistance to chemotherapy may be present at the beginning of
treatment, develop during treatment, or become apparent on re-treatment of the patient. The …

Background SARS-CoV-2 lineage B. 1.1. 7 has been associated with an increased rate of
transmission and disease severity among subjects testing positive in the community. Its …

Background Activation of the epidermal growth factor receptor (EGFR) triggers downstream
signaling pathways that regulate many cellular processes involved in tumour survival and …

Pentamidine is a small molecule inhibitor of the Ca 2+-binding protein S100B and disrupts
the S100B–p53 protein–protein interaction; this is thought to restore wild-type p53 tumour …

Background The first epidemic wave of severe acute respiratory syndrome coronavirus-2
(SARS-CoV-2) in Scotland resulted in high case numbers and mortality in care homes. In …

Throughout the COVID-19 pandemic, valuable datasets have been collected on the effects
of the virus SARS-CoV-2. In this study, we combined whole genome sequencing data with …

Abstract Objectives: Recently emerging SARS-CoV-2 variants have been associated with an
increased rate of transmission within the community. We sought to determine whether this …