Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers

S Kyo, M Takakura, T Fujiwara, M Inoue - Cancer science, 2008 - Wiley Online Library
Telomerase activation is a critical step for human carcinogenesis through the maintenance
of telomeres, but the activation mechanism during carcinogenesis remains unclear …

Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression

LB Owen-Schaub, W Zhang, JC Cusack… - … and cellular biology, 1995 - Am Soc Microbiol
Fas/APO-1 is a cell surface protein known to trigger apoptosis upon specific antibody
engagement. Because wild-type p53 can activate transcription as well as induce apoptosis …

Clinical impact of sarcopenia on gastric cancer

K Kuwada, S Kuroda, S Kikuchi, R Yoshida… - Anticancer …, 2019 - ar.iiarjournals.org
Sarcopenia is a complex syndrome defined by progressive and generalized loss of skeletal
muscle mass and strength. Although sarcopenia is mainly associated with aging, cancer is …

Induction of Chemosensitivity in Human Lung Cancer Cells in Vivo by Adenovirus-mediated Transfer of the Wild-Type p53 Gene

T Fujiwara, EA Grimm, T Mukhopadhyay, WW Zhang… - Cancer Research, 1994 - AACR
Recombinant adenovirus-mediated transfer of the wild-type p53 gene into monolayer
cultures or multicellular tumor spheroids of human non-small cell lung cancer cell line H358 …

Circular RNA ciRS-7—a promising prognostic biomarker and a potential therapeutic target in colorectal cancer

W Weng, Q Wei, S Toden, K Yoshida, T Nagasaka… - Clinical Cancer …, 2017 - AACR
Purpose: Colorectal cancer is one of the most common malignancies worldwide. Recently, a
novel circular RNA, ciRS-7, was proposed to be a potential miR-7 sponge. As miR-7, a …

Prevention of acute liver failure in rats with reversibly immortalized human hepatocytes

N Kobayashi, T Fujiwara, KA Westerman, Y Inoue… - Science, 2000 - science.org
Because of a critical shortage in suitable organs, many patients with terminal liver disease
die each year before liver transplantation can be performed. Transplantation of isolated …

Advances in adenovirus-mediated p53 cancer gene therapy

H Tazawa, S Kagawa, T Fujiwara - Expert opinion on biological …, 2013 - Taylor & Francis
Introduction: The tumor suppressor p53 gene regulates diverse cellular processes, such as
cell-cycle arrest, senescence, apoptosis and autophagy, and it is frequently inactivated by …

[HTML][HTML] A phase I study of telomerase-specific replication competent oncolytic adenovirus (telomelysin) for various solid tumors

J Nemunaitis, AW Tong, M Nemunaitis, N Senzer… - Molecular therapy, 2010 - cell.com
A phase I clinical trial was conducted to determine the clinical safety of Telomelysin, a
human telomerase reverse transcriptase (hTERT) promoter driven modified oncolytic …

Telomerase-specific replication-selective virotherapy for human cancer

T Kawashima, S Kagawa, N Kobayashi… - Clinical Cancer …, 2004 - AACR
Purpose: Replication-selective tumor-specific viruses present a novel approach for treating
neoplastic disease. These vectors are designed to induce virus-mediated lysis of tumor cells …

Cancer-Associated Fibroblasts Affect Intratumoral CD8+ and FoxP3+ T Cells Via IL6 in the Tumor Microenvironment

T Kato, K Noma, T Ohara, H Kashima, Y Katsura… - Clinical Cancer …, 2018 - AACR
Abstract Purpose: Cancer-associated fibroblasts (CAFs) in the tumor microenvironment
(TME) play a central role in tumor progression. We investigated whether CAFs can regulate …