Waking genioglossal electromyogram in sleep apnea patients versus normal controls (a neuromuscular compensatory mechanism).

WS Mezzanotte, DJ Tangel… - The Journal of clinical …, 1992 - Am Soc Clin Investig
Pharyngeal collapse in obstructive sleep apnea patients is likely a product of a sleep-related
decrement in pharyngeal dilator muscle activity superimposed upon abnormal airway …

Influence of sleep on tensor palatini EMG and upper airway resistance in normal men

DJ Tangel, WS Mezzanotte… - Journal of applied …, 1991 - journals.physiology.org
We propose that a sleep-induced decrement in the activity of the tensor palatini (TP) muscle
could induce airway narrowing in the area posterior to the soft palate and therefore lead to …

Influence of Sleep on Genioglossus Muscle Adivation by Negative Pressure in Normal Men

JR Wheatley, WS Mezzanotte, DJ Tangel… - American Review of …, 1993 - atsjournals.org
METHODS We studied six normal, healthy male volunteers (age 27.8±2.2 [SEMI yr, height
176.8±1.8 ern, and weight 76.4±3.5 kg). The subjects were regular nocturnal sleepers with …

Design of the PF-ILD trial: a double-blind, randomised, placebo-controlled phase III trial of nintedanib in patients with progressive fibrosing interstitial lung disease

KR Flaherty, KK Brown, AU Wells… - BMJ open …, 2017 - bmjopenrespres.bmj.com
600 patients aged≥ 18 years will be randomised in a 1: 1 ratio to nintedanib or placebo.
Patients with diagnosis of IPF will be excluded. The study population will be enriched with …

Eosinophilia, frequent exacerbations, and steroid response in chronic obstructive pulmonary disease

PMA Calverley, K Tetzlaff, C Vogelmeier… - American journal of …, 2017 - atsjournals.org
Inhaled corticosteroids (ICSs), together with long-acting bronchodilators, are recommended
for patients with severe chronic obstructive pulmonary disease (COPD) and a history of …

Influences of NREM sleep on the activity of tonic vs. inspiratory phasic muscles in normal men

DJ Tangel, WS Mezzanotte… - Journal of applied …, 1992 - journals.physiology.org
Studies of sleep influences on human pharyngeal and other respiratory muscles suggest
that the activity of these muscles may be affected by non-rapid-eye-movement (NREM) sleep …

Influence of sleep on response to negative airway pressure of tensor palatini muscle and retropalatal airway

JR Wheatley, DJ Tangel… - Journal of applied …, 1993 - journals.physiology.org
Increased retropalatal airway resistance may be caused by a sleep-induced loss of palatal
muscle activity and a diminished ability of these muscles to respond to the increasing …

Effect of age on response to zafirlukast in patients with asthma in the Accolate Clinical Experience and Pharmacoepidemiology Trial (ACCEPT)

PE Korenblat, JP Kemp, JE Scherger… - Annals of Allergy …, 2000 - Elsevier
BACKGROUND: The Accolate Clinical Experience and Pharmacoepidemiology Trial
(ACCEPT), evaluated zafirlukast in a wide spectrum of patients from a variety of clinical …

Twelve-week, randomized, placebo-controlled, multicenter study of the efficacy and tolerability of budesonide and formoterol in one metered-dose inhaler compared …

J Corren, PE Korenblat, CJ Miller, CD O'Brien… - Clinical …, 2007 - Elsevier
BACKGROUND:: The addition of the long-acting β2-adrenergic agonist formoterol to low-to
moderate-dose budesonide has shown clinical efficacy in patients with persistent asthma …

Influences of NREM sleep on activity of palatoglossus and levator palatini muscles in normal men

DJ Tangel, WS Mezzanotte… - Journal of Applied …, 1995 - journals.physiology.org
Most evidence indicates that palatal position has an important influence on respiration
during sleep. We have previously demonstrated during wakefulness that the levator palatini …