Background Tuberculosis (TB) is a major public health problem and at 48%, Karamoja in
North-Eastern Uganda has the lowest treatment success rate nationally. Addressing the …

Rationale Detailed data on the characteristics and outcomes of patients with COVID-19 in
sub-Saharan Africa are limited. Objective We determined the clinical characteristics and …

Objective We undertook a systematic review of strategies adopted to scale up COVID-19
testing in countries across income levels to identify successful approaches and facilitate …

Rationale Convalescent plasma (CCP) has been studied as a potential therapy for COVID-
19, but data on its efficacy in Africa are limited. Objective In this trial we set out to determine …

Background Tuberculosis (TB) patients in Uganda incur large costs related to the illness,
and while seeking and receiving health care. Such costs create access and adherence …

Prior research suggests that fluvoxamine, a selective serotonin reuptake inhibitor (SSRI)
used for the treatment of obsessive-compulsive disorder and major depressive disorder …

Background Equitable access to affordable medicines and diagnostic tests is an integral
component of optimal clinical care of patients with asthma and chronic obstructive …

Background Undernutrition is associated with unfavourable treatment outcomes among
people with drug-resistant tuberculosis (DRTB). Factors influencing the treatment outcomes …

Africa in 2013–2016, the World Health Organization (WHO) fast-tracked the development
and testing of therapeutic agents and vaccines against the Zaire strain, the causative agent …

Background Determining mycobacterial burden is important in assessing severity of
disease, evaluating infectiousness and predicting patient treatment outcomes. Mycobacterial …