Study objectives: Significant morbidity and mortality offset the benefits of lung volume
reduction surgery (LVRS) for emphysema. By contributing to distal lung collapse …

Aims The aim of this study was to compare the variability and sensitivity of impulse
oscillometry (R5, X5 and RF), plethysmography (Raw and sGaw) and spirometry (FEV1 …

BACKGROUND: Impulse oscillometry system (IOS) assesses pulmonary resistance and
reactance. We set out to investigate which IOS measurements are related to airflow …

The p38 mitogen‐activated protein kinase (MAPK) signaling upregulates inflammation and
is known to be increased in chronic obstructive pulmonary disease (COPD). The authors …

What is already known about this subject• Forced expiratory voume in 1 s (FEV1) is the
standard measurement used to measure drug effects in chronic obstructive pulmonary …

Background Many of the systemic manifestations of chronic obstructive pulmonary disease
(COPD) are mediated through increased systemic levels of inflammatory proteins. We …

Background Airway inflammation in COPD can be measured using biomarkers such as
induced sputum and Fe NO. This study set out to explore the heterogeneity of COPD using …

INTRODUCTION: Exhaled nitric oxide (NO) is an established technique for monitoring
airway inflammation. We have compared exhaled NO measurements from 3 different …

Limited information exists regarding measurement, reproducibility and interrelationships of
non-invasive biomarkers in smokers. We compared exhaled breath condensate (EBC) …

The reproducibility of exhaled breath condensate (EBC) mediators is not well documented in
chronic obstructive pulmonary disease (COPD). This study assessed within assay (WA) …