Background Research has underscored the effects of exposure and sensitization to allergens
on the severity of asthma in inner-city children. It has also revealed the limitations of …

Lung disease is the major cause of morbidity and mortality in patients with cystic fibrosis (CF).
Although CF lung disease is primarily an infectious disorder, the associated inflammation …

Importance Many preschool children develop recurrent, severe episodes of lower respiratory
tract illness (LRTI). Although viral infections are often present, bacteria may also contribute …

Cystic Fibrosis (CF) lung disease, which is characterized by airway obstruction, chronic
bacterial infection, and an excessive inflammatory response, is responsible for most of the …

Cystic fibrosis (CF) lung disease is characterized by a self-perpetuating cycle of airway
obstruction, chronic bacterial infection, and vigorous inflammation that results in structural …

Background Phenotypic presentations in young children with asthma are varied and might
contribute to differential responses to asthma controller medications. Methods The …

The host inflammatory response in cystic fibrosis (CF) lung disease has long been recognized
as a central pathological feature and an important therapeutic target. Indeed, many …

… Correspondence and requests for reprints should be addressed to James F. Chmiel, MD,
MPH, Division of Pediatric Pulmonology and Allergy/Immunology, Room 3001, Rainbow …

Inflammation plays a critical role in cystic fibrosis (CF) lung pathology and disease progression
making it an active area of research and important therapeutic target. In this review, we …

Our objectives were to characterise the microbiota in cystic fibrosis (CF) bronchoalveolar
lavage fluid (BALF), and determine its relationship to inflammation and disease status. BALF …