Most Cited Articles

This page highlights the top cited articles published in BMJ Open Respiratory Research from the past 3 years to celebrate the high quality of respiratory medicine, critical care and sleep medicine research published by the journal.


Safety and survival data in patients with idiopathic pulmonary fibrosis treated with nintedanib: pooled data from six clinical trials
Lisa Lancaster, Bruno Crestani, Paul Hernandez, et al.

Guidelines on the management of acute respiratory distress syndrome
Mark J.D. Griffiths, Danny Francis McAuley, Gavin D. Perkins, et al.

Rationale, design and objectives of two phase III, randomised, placebo-controlled studies of GLPG1690, a novel autotaxin inhibitor, in idiopathic pulmonary fibrosis (ISABELA 1 and 2)
Toby M. Maher, Michael Kreuter, David J. Lederer, et al. 

Multicentre pilot randomised clinical trial of early in-bed cycle ergometry with ventilated patients
Michelle E. Kho, Alexander J. Molloy, France J. Clarke, et al.

Cell therapy for ARDS: efficacy of endobronchial versus intravenous administration and biodistribution of MAPCs in a large animal model
Nayra Cardenes, Paola Aranda-Valderrama, Jonathan P. Carney, et al.

Use of bubble continuous positive airway pressure (bCPAP) in the management of critically ill children in a Malawian paediatric unit: an observational study
Sarah Myers, Precious Dinga, Margot Anderson, et al.


Pirfenidone in patients with unclassifiable progressive fibrosing interstitial lung disease: design of a double-blind, randomised, placebo-controlled phase II trial
Toby Maher, Tamera Corte, Aryeh Fischer, et al.

Chronic obstructive pulmonary disease associated with biomass fuel use in women: a systematic review and meta-analysis
Adama Sana, Serge M. Somda, Nicolas Meda, Catherine Bouland

British Thoracic Society Quality Standards for acute non-invasive ventilation in adults
Michael Davies, Martin Allen, Andrew Bentley, et al.

Randomised controlled trial to compare the diagnostic yield of positron emission tomography CT (PET-CT) TARGETed pleural biopsy versus CT-guided pleural biopsy in suspected pleural malignancy (TARGET trial)
Duneesha de Fonseka, Wendy Underwood, Louise Stadon, et al.

Metabolomics of World Trade Center-Lung Injury: a machine learning approach
George Crowley, Sophia Kwon, Syed Hissam Haider, et al.

Investigating the effects of nintedanib on biomarkers of extracellular matrix turnover in patients with IPF: design of the randomised placebo-controlled INMARK (R) trial
Toby M. Maher, Susanne Stowasser, Yasuhiko Nishioka, et al.

Psychometric properties of the St George’s Respiratory Questionnaire in patients with idiopathic pulmonary fibrosis: insights from the INPULSIS trials
Jeffrey J. Swigris, Hilary Wilson, Dirk Esser, et al.

Dose modification and dose intensity during treatment with pirfenidone: analysis of pooled data from three multinational phase III trials
Steven D. Nathan, Lisa H. Lancaster, Carlo Albera, et al.

British Thoracic Society Guideline for the initial outpatient management of pulmonary embolism
Luke S. Howard, Steven Barden, Robin Condliffe, et al.

Randomised clinical trial of an early palliative care intervention (SUPPORT) for patients with idiopathic pulmonary fibrosis (IPF) and their caregivers: protocol and key design considerations
Kathleen Oare Lindell, Mehdi Nouraie, Melinda J. Klesen, et al.


Effect of a machine learning-based severe sepsis prediction algorithm on patient survival and hospital length of stay: a randomised clinical trial
David Shimabukuro, Christopher Barton, Mitchell Feldman, et al.

British Thoracic Society Guideline for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD)
Charles Haworth, John Banks, Toby Capstick, et al.

Metabolic heterogeneity of idiopathic pulmonary fibrosis: a metabolomic study
Yidan Zhao, Li Yin, Stephen Archer, et al.

Design of the PF-ILD trial: a doubleblind, randomised, placebo-controlled phase III trial of nintedanib in patients with progressive fibrosing interstitial lung disease
Kevin Flaherty, Kevin Brown, Athol Wells, et al.

British Thoracic Society Guideline for oxygen use in adults in healthcare and emergency settings
B.R. O’Driscoll, L.S. Howard, J. Earis, V. Mak

Assessment of patient-reported outcome measures in pleural interventions
Ioannis Psallidas, Ahmed Yousuf, Ambika Talwar, et al.

Rural to urban migration is associated with increased prevalence of childhood wheeze in a Latin-American city
Alejandro Rodriguez, Maritza Vaca, Martha Chico, et al.

Timing of hypertonic saline and airway clearance techniques in adults with cystic fibrosis during pulmonary exacerbation: pilot data from a randomised crossover study
Katherine O’Neill, Fidelma Moran, Michael M. Tunney, et al.

Predictive value of prebronchodilator and postbronchodilator spirometry for COPD features and outcomes
Spyridon Fortis, Michael Eberlein, Dimitris Georgopoulos, Alejandro Comellas

Alcohol drinking and cigarette smoking in relation to risk of active tuberculosis: prospective cohort study
Avril Zixin Soh, Cynthia Bin Eng Chee, Yee-Tang Wang, et al.